balloonlike dilatation of cerebral bloodvessels intracranial aneurysms
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with untreated unruptured aneurysms in or near the circle of Willis, found incidentally, in screening populations or in patients with multiple aneurysms - Planned for endovascular treatment at the AMC - Age 18- 70 yrs - Written informed consent
Exclusion criteria
Exclusion criteria: contrast allergy, impared renal function, contra-indications for MRI (pacemaker, claustrofobia, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters: - measurement of flow velocities (in cm/s) in blood vessels proximal and distal of intracranial aneurysms as well as within the aneurysms. Flow velocities will be derived from invasive endovascular measurements using the ComboWire® and from non-invasive 4D phase-contrast MRA measurements. - measurements of pressure (mmHg) in blood vessels surrounding intracranial aneurysms and within the aneurysm, using ComboWire®. Primary outcome: - Comparisons of flow velocity measurements in individual patients between invasive and non-invasive techniques to assess the accuracy of 4D phase-contrast MRA in measuring flow velocity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters: - Measurement of the aneurysm wall displacement on 3DRA and 4D MRA images. - Visual scores and quantative measurements of aneurysm morphology by two neuroradiologists based on 3DRA imaging and Maximum Intensity Projection (MIP) MRA images. Secondary outcome: - The construction of a computational model of aneurysm wall elasticity based on pressure measurements and aneurysm wall distensibility. - The determination of a relation between aneurysm morphology and its local flow velocity and pressure. - Modelling of local hemodynamics of intracranial aneurysms. | — |
Countries
Netherlands
Outcome results
None listed