Early post-trauma and post-surgery neutrophil functions in the development of ARDS

Early post-trauma and post-surgery neutrophil functions in the development of ARDS - Neutrophil functions in ARDS (NEUTRON-study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31246

Enrollment

Registered

2007-11-06

Start date

2007-12-04

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute lung injury (ALI) shock lung

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adults: patients* age between 18 and 65 years Early blood sample available (

Exclusion criteria

Exclusion criteria: A pre-existing condition that alters PMN function. (e.g. leukemia, use of prednisolone or other immunosuppressant drugs)

Design outcomes

Primary

Measure	Time frame
Primary study parameters: The functional response of PMNs at high doses of chemostimulants Primary outcome: The lowest PaO2/FiO2 ratio exhibit during the first three days after the initial trauma or surgery. (i.e. the degree of respiratory failure)	—

Secondary

Measure	Time frame
Secondary study parameters: - the slope (steepness) op the dose response curves Secondary study endpoints: Development of ALI/ ARDS: - Acute onset - Pulmonary artery wedge pressure	—

Countries

Netherlands

Outcome results