Pathogenetic insights in idiopathic orbital inflammation

Pathogenetic insights in idiopathic orbital inflammation - Idiopathic orbital inflammation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31228

Enrollment

Registered

2007-08-28

Start date

2007-10-24

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

idiopathic orbital inflammation nonspecific orbital inflammation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patients presenting to the ophthalmology clinic with signs of (sub) acute infiltration and inflammation of intraorbital structures together with symptoms of eyelidedema, conjunctival injection, chemosis, pain and/or motilitydisturbances who have an orbital biopsy planned for a presumed orbital pseudotumor as part of regular medical care.

Exclusion criteria

Exclusion criteria: Exclusion of identifiable local causes such as neoplasia and primary infection. No informed consent. No biopsy planned.

Design outcomes

Primary

Measure	Time frame
Higher prevalence of certain virussen/bacteria in the study group compared with controls. Differential expression of proteins involved in inflammation and tissue (re-)generation in the study group compared with controls.	—

Secondary

Measure	Time frame
Differential expression of proteins involved in inflammation and tissue (re-)generation within the study subgroups dacryoadenitis, myositis, sclerosing and diffuse. Quality of life of patients suffering from idiopathic orbital inflammation.	—

Countries

Netherlands

Outcome results