mucoviscoidosis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: signed informed consent, able to comply with protocol requirements, diagnosis of CF confirmed, age 6-18 years, stable condition, ability to perform lung function tests and breathhold manoeuvres, CT in the year before the MRI.
Exclusion criteria
Exclusion criteria: Exclusion criteria: inability to follow instructions of the investigator, current respiratory infection requiring IV antibiotics, pulmonary complications that might put patient at risk to participate , claustrophobia, history of anaphylactic reaction on contrast agent, any clinical condition which, according to the treating physician, might put patient at risk, severe asthma and/or severe allergies as determined by physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ability of the radiologist and CF team to identify areas of the lung that are hypo perfused on the Gd-MRI relative to the proton-MRI. The distribution and volume of hypo perfused lung on the Gd-MRI will be compared to the distribution of trapped air on the proton-MRI and with the chest CT made in the previous year. After completion of the study all CTs and Gd-MRIs will be scored anonymous and in random order using a semi quantitative scoring system. | — |
Secondary
| Measure | Time frame |
|---|---|
| The ability of the radiologist and CF team to identify progression of peripheral bronchiectasis compared to the CT made in the previous year. | — |
Countries
Netherlands
Outcome results
None listed