Mitochondrial dysfunction in genetic parkinsonism: what muscles can tell us about the brain

Mitochondrial dysfunction in genetic parkinsonism: what muscles can tell us about the brain - Mitochondrial dysfunction in genetic parkinsonism

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31198

Enrollment

Registered

2008-01-14

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with a proven autosomal recessive Parkinson's disease carrying the parkin mutation.

Exclusion criteria

Exclusion criteria: age under 18 years dementia use of anticoagulants

Design outcomes

Primary

Measure	Time frame
Histology: 1. presence and number of Cox-negative fibres 2. morphology of the mitochondriae Mitochondrial: 1. substrate oxidations 2. ATP metabolism 3. enzyme activity (complex I to V)	—

Secondary

Measure	Time frame
No secundary outcome parameters	—

Countries

Netherlands

Outcome results