geen aandoening nvt
Conditions
Interventions
Participants will be treated with biperiden, rivastigmine, a combination, or a
placebo. All treatments will be taken orally. The treatment order will be
established by counterbalancing.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or female, between 18 and 25 years of age, healthy (absence of exclusion criteria), normal static binocular activity, body mass index between 18.5 and 30, willingness to sign an informed consent.
Exclusion criteria
Exclusion criteria: history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the behavioural score on the verbal learning task (VLT), the continuous recognition memory task (CRMT), and the spatial memory task (SMT). Secondary, the event-related potentials during those tasks will be analysed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Another important parameter is the change in behavioural and brain response to the choice reaction time task, since this measures a possible sedative effect of the two drugs. | — |
Countries
Netherlands
Outcome results
None listed