Huntington's disease
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Ability to tolerate MRI and sample donation;• Subjects will be either: 1. Control subject a. Partner/spouse of a patient, not at risk of HD b. Known non-carriers for HD (after genetic testing);2. Premanifest gene carrier a. Positive genetic test with CAG repeat length >= 40 and b. Burden of pathology score [(CAG-35.5) × age] >250 and c. Absence of diagnostic motor features according to the UHDRS 99;3. Early HD a. Positive genetic test with CAG repeat length >= 40 and b. Presence of diagnostic motor features according to the UHDRS 99 and c. Shoulson and Fahn stage 1 (TFC > 9-13) or 2 (TFC >= 7) according to the UHDRS 99 - functional capacity
Exclusion criteria
Exclusion criteria: • Stage 3 (TFC
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All variables are considered to be primary study parameters: clinical, MRI, genetics and biomarkers to determine which combination is the most sensitive to detect changes in the natural course of HD. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dependant on results on the primary outcome variables. | — |
Countries
Netherlands
Outcome results
None listed