Effect of mechanical ventilation on plasma cytokine concentrations in healthy humans

Effect of mechanical ventilation on plasma cytokine concentrations in healthy humans - Mechanical ventilation and cytokine release

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31169

Enrollment

Registered

2007-07-16

Start date

2007-08-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventilation-induced lung injury

Interventions

Patients will undergo general anaesthesia 2 hours before the scheduled start of the surgical procedure. Anaesthesia will be given according to standardized protocol. Patients are assigned to one of

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Between 18-65 years old, American Society of Anesthesiologists (ASA) status 1 or 2, ability to speak Dutch, body weight between 60-100 kg/s with a BMI

Exclusion criteria

Exclusion criteria: Patients with pulmonary, cardiac, hepatic or renal disease or significant or instable disease of the central nervous system, patients that smoke, use of (N)SAID's within 36 hours of surgery, history of drug dependency or drug abuse, BMI >30 kg/m2 or

Design outcomes

Primary

Measure	Time frame
The main study parameter is the measurement of the systemic cytokine (IL-1alpha, IL-1beta, IL-6, IL-8, KC, TNF-alpha) release. The experiment ends after the final blood sample has been obtained after surgery.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)