The effect of biological and environmental factors on the course of cognition in First Episode Schizophrenia patients and High Risk Subjects

The effect of biological and environmental factors on the course of cognition in First Episode Schizophrenia patients and High Risk Subjects - The Effect of biology and environment on cognition in schizophrenia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31164

Enrollment

150

Registered

2008-03-03

Start date

2007-10-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychosis schizophrenia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: The First Episode Schizophrenia patients will have to meet the DSM-IV criteria for schizophrenia and this diagnosis should not have been assessed in the past. The Ultra High Risk patients will be assessed using the Structured Interview of Prodromal Symptoms (SIPS) and

Exclusion criteria

Exclusion criteria: pregnancy, metals in the body contraindicated in MRI inverstigation

Design outcomes

Primary

Measure	Time frame
The most important study parameters are the results of the cognitive test battery MATRICS with an interval of 1 year. Using the MATRICS the course of cognitive functioning can be assessed and in the High Risk group, the persons that make the transition to psychosis can be tested for changes in cognitive functioning	—

Secondary

Measure	Time frame
The secundary study parameters are the biological data (MRI, genetics), behavioral data (Pre Pulse Inhibition) and environmental data (cannabis use) that are linked to the cognitive data. In this manner potential predisposing factors for cognitive functioning can be identified.	—

Countries

Netherlands

Outcome results