Nasal colonisation S. aureus
Conditions
Interventions
14 volunteers are inoculated with S. aureus strain 8325-4 with IEC (1.10exp7
colony forming units per nostril)
14 volunteers are inoculated with S. aureus strain 8325-4 without IEC (1.10exp7
colony
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy individuals older than 18 years The volunteer has given informed consent
Exclusion criteria
Exclusion criteria: Individuals with age below 18 years. Volunteers with diabetes mellitus, renal insufficiency, COPD, heart diseases, immunocompromised status (HIV, AIDS) or use of immunosuppressants, allergy for mupirocin or penicillin, skin diseases such as eczema and psoriasis. Volunteers who have close contact with individuals suffering from the afflictions mentioned above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between the strain with and without IEC in persistence on the nasal epithelium in time. This is measured by counting the number of colony forming units on blood agar plates after microbiological culture of the nostrils. | — |
Countries
Netherlands
Outcome results
None listed