CABG
Conditions
Interventions
Group A will receive in a 1 block period of 15-min: 65% xenon together with
35% oxygen,
Groep B will receive in 3 blocks of 5-min per block with an intercept of 5 min
between the blocks: 65% xenon t
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age range: 18 years or older Patients who have to undergo elective cardiac surgery (CABG with or without valve surgery) Written informed consent All inclusion criteria must be met; otherwise the patient cannot be enrolled into the study
Exclusion criteria
Exclusion criteria: Age range:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The present application of xenon seeks to investigate the mechanisms behind xenon preconditioning in humans. This will be done by examination of 3 myocardial tissue probes (called A, B and C) per patient (numbered 1, 2, 3, etc.) in a molecular laboratory setting detecting activity of PKC-e, p38MAPK, JNK and ERK. For transport purposes the probes will be preserved in Eppendorf® cups placed into liquid nitrogen (-30 °C). | — |
Secondary
| Measure | Time frame |
|---|---|
| Troponin T, CPK, CPK-MB, pro-BNP and S-100 protein levels will be examined both before operation and during the first 24 hours of the ICU period after the operation. | — |
Countries
Netherlands
Outcome results
None listed