Quantitative and qualitative analysis of cortisol and adrenocorticotrophic hormone (ACTH) secretion in patients with subclinical Cushing syndrome (SCS) and bilaterally enlarged adrenal glands

Quantitative and qualitative analysis of cortisol and adrenocorticotrophic hormone (ACTH) secretion in patients with subclinical Cushing syndrome (SCS) and bilaterally enlarged adrenal glands - Cortisol and ACTH secretion in SCS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31116

Enrollment

Registered

2007-09-07

Start date

2007-07-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical Cushing Syndrome Subclinical Hypercortisolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients known at the outpatient clinic of Endocrine Diseases in the UMCN St. Radboud, with subclinical Cushing syndrome with bilateral adrenal pathology

Exclusion criteria

Exclusion criteria: Patients with SCS in whom adrenalectomy has been done, and patients with SCS and unilateral adrenal involvement and patients with SCS due to pituitary pathology

Design outcomes

Primary

Measure	Time frame
Cortisol and ACTH rhythm expressed as frequency/amplitude and regularity of cortisol and ACTH secretory pulses.	—

Secondary

Measure	Time frame
Comparance of cortisol and ACTH rhythm expressed as frequency/amplitude and regularity of cortisol and ACTH secretory pulses of patients with subclinical cushing syndrome to patients with full-blown Cushing syndrome and healthy controls, previously investigated by means of 10 minute sampling in the LUMC in Leiden.	—

Countries

Netherlands

Outcome results