insuline secretie en eetlust regulatie - appetite: hunger/satiety
Conditions
Interventions
Participants will drink daily a test substance for three weeks (2 cans of
Amstel beer per day
66 cL ~ 26 gram alcohol) followed by a reference substance
(2 cans of Amstel alcohol-free beer per day
66 cL
Sponsors
Stichting Alcohol Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Healthy as assessed by the health and lifestyle questionnaire (P7573 F02; in Dutch), physical examination and results of the pre-study laboratory tests 2. Females between 20 - 44 years of age at day of inclusion 3. Using oral contraceptives for >3 months (only phase 1 or 2 oral contraceptives) 4. Normal fasting glucose levels as indicated by venous fasting plasma glucose levels
Exclusion criteria
Exclusion criteria: 1. Having the intention to become pregnant, to be pregnant or to lactate during the study 2. Participation in any clinical trial including blood sampling and/or administration of substances up to 90 days before Day 01 of this study 3. Participation in any non-invasive clinical trial up to 30 days before day 01 of the study, including no blood sampling and/or oral, intravenous, inhalatory administration of substances 4. Having a history of medical or surgical events that may significantly affect the study outcome including metabolic or endocrine disease, gastro-intestinal disorder, or eating behavior disorders such as anorexia/bulimia disorders 5. Having a family history of alcoholism 6. Mental or physical status that is incompatible with the proper conduct of the study 7. Use of medication that may affect the outcome of the study parameters (except oral contaceptives) 8. Smoking 9. Reported use of any soft or hard drugs 10. Reported unexplained weight loss or gain of > 3 kg in the month prior to the screen¬ing 11. Reported slimming or medically prescribed diet 12. Reported vegetarian, vegan or macrobiotic 13. Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial insulin secretion and pancreatic beta-cell function: For postprandial insulin secretion main parameters are (i)AUC of glucose, C-peptides and insulin after a lunch. Main parameters of pancreatic beta-cell function are glucose sensitivity, rate sensitivity and potentiation (§ 14.3.3). These parameters can be derived from mathematical modelling (P7573 B08). C-peptides, glucose and insulin concentrations will be used as input for the mathematical model. Physiological and subjective parameters related to satiety and appetite physiological parameters :of satiety such such as gut hormone concentrations and endocannabinoids subjective measuresof satiety such: subjective ratings of appetite and postprandial wellness (PPW) questions on visual analogue scales (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Miscellaneous markers of glucose homeostasis and insulin sensitivity Concentrations of miscellaneous markers of glucose homeostasis and insulin sensitivity, such as HbA1c, fructosamine, apelin, obestatin, visfatin. Kinetics of alcohol-induced increase in adiponectin Adiponectin concentrations at baseline and after one, two and three weeks of treatment. Gene expression in subcutaneous adipose tissue mRNA expression of genes corresponding to metabolic pathways involved in glucose and fatty acid metabolism. | — |
Countries
Netherlands
Outcome results
None listed