TB tuberculosis
Conditions
Interventions
None listed
Sponsors
Koninklijk Instituut voor de Tropen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients suspected of having TB. Some of these will be ZN positive and later confirmed by a positive M. tuberculosis culture; these will be the confirmed TB patients. The Non-TB patients will have a negative Ziehl-Neelsen (ZN) and a negative sputum culture for M. tuberculosis. For Children we will use ZN positive patients or culture positive patients or clinical and epidemiological evidence (family member with active TB) of TB and response to anti TB treatment. The non TB children are initially suspected for having TB but were later found to have another disease.;Cough for more than two weeks Weight loss abnormal chest x ray chest infection suspected For those under 18 years old, able to voluntarily give a urine specimen
Exclusion criteria
Exclusion criteria: Patients unable to understand nature of study and so unable to give proper informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The GC-MS and PTR-MS VOC profiles will be anlysed by statistical methods e.g. principal component anlysis, linear discriminant function analysis (DFA), Partial least square (PLS) analysis. and artificial neural networ. The smell profiles of the electronic nose will be analysed in the same way as the GC-MS VOC profiles. The outcome will be a set of VOCs characteristic for tuberculosis. Part of the VOCs will be derived from the mycobacteria and part from the host. Perhaps the host VOCs can divided in infection disease related and TB specific VOCs. | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
Netherlands
Outcome results
None listed