Erythropoietin and coronary collateral flow in patients with coronary artery disease

Erythropoietin and coronary collateral flow in patients with coronary artery disease - EPO and coronary collateral flow

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31082

Enrollment

110

Registered

2007-11-20

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

angina myocardial ischemia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Group A • Men and women > 18 years of age • A positive stress test or symptoms related to stable CAD • Patients who are scheduled for an elective PCI for 1 significant stenotic lesion ;Group B: • Men and women > 18 years of age • Patients with an acute coronary syndrome, defined as having unstable angina with elevated troponins • During the coarse of the PCI procedure it has become clear that a single occlusion needs to be revascularised.;Group C: • Men and women > 18 years • Patients who are seen at the outpatient clinic and in whom cardiac disease is excluded • Exclusion of cardiac disease is established by laboratory tests, electrocardiogram, echocardiography and/or an exercise test.

Exclusion criteria

Exclusion criteria: Group A and B:;• Previous myocardial infarction • Previous CABG • Signs of AMI on ECG • Moderate renal failure (eGFR

Design outcomes

Primary

Measure	Time frame
To assess the correlation between endogenous EPO levels and coronary collateral flow	—

Secondary

Measure	Time frame
The secundary objectives are: - to assess if there are differences in endogenous EPO leves, EPC levels and EPC function in patients with stable and unstable CAD, compared to age and sex matched controls; - to explore the correlation between the number of functional EPCs and the extent of coronary collateral flow in patients with stable and unstable angina; - to study the effect of resolving the coronary artery stenosis on endogenous EPO and EPC levels/function before and after the PCI procedure.	—

Measure

Time frame

The secundary objectives are: - to assess if there are differences in endogenous EPO leves, EPC levels and EPC function in patients with stable and unstable CAD, compared to age and sex matched controls; - to explore the correlation between the number of functional EPCs and the extent of coronary collateral flow in patients with stable and unstable angina; - to study the effect of resolving the coronary artery stenosis on endogenous EPO and EPC levels/function before and after the PCI procedure.

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Countries

Netherlands

Outcome results