Insulin sensitivity in appropriate for gestational age and small for gestational age term and preterm infants

Insulin sensitivity in appropriate for gestational age and small for gestational age term and preterm infants - Insulin sensitivity in AGA and SGA term and preterm infants.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31057

Enrollment

Registered

2007-07-16

Start date

2007-04-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

decreased sensitivity to blood sugar regulating hormone insulin sensitivity

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: - Need for blood sampling on a clinical indication, e.g. for neonatal screening program or before discharge home. - (Near) term age at the moment of blood sampling (corrected postconceptional age 36-42 weeks) - Full oral or enteral nutrition (>120 ml/kg/day)

Exclusion criteria

Exclusion criteria: - Uncertain gestational age - Supplementary intravenous nutrition (parenteral nutrition or glucose infusion) - Disturbances in glucose metabolism (hypo- or hyperglycemia at a normal carbohydrate intake, or need for insulin therapy to maintain glucose concentration between 2.6 and 8 mmol/l) - Need for medication interfering with glucose metabolism (vasopressors, corticosteroids) - Positive family history of type 2 diabetes in first degree relatives - Perinatal asphyxia (5 minute Apgar score

Design outcomes

Primary

Measure	Time frame
Primary outcome is insulin sensitivity measured by homeostasis model (IR-HOMA). This requires a single blood sample for glucose and insulin concentrations.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results