abdominal aortic aneurysm
Conditions
Interventions
doxycyline 100 mg
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Patients with an abdominal aortic aneurysm • The diameter should be 3.5 - 5.0 cm (Group A) • The diameter is > 5.5 cm and the patient is unfit for operation or refuses intervention (Group B) • Follow-up with ultrasound should be possible (obesity)
Exclusion criteria
Exclusion criteria: • Unable to comply with follow-up • Contra indications for doxycycline (excessive sun exposure) • Known impaired liver function (ALAT >3-fold normal values) or known kidney dysfunction (estimate clearance less than 40 ml/min) • Excessive sun exposure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aneurysm progression at t=18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Seconday outcome measures are growth at 6 and 12 months, need for elective aneurysm repair, rupture, death, and an inventory of possible side-effects (questionnaire). Moreover, possible beneficial effects of doxycycline therapy on the progression of atherosclerosis and emphysema will be evaluated by assessment of intima media thickness (carotid artery), plasma inflammatory markers (CRP, fibrinogen) and endothelial cell markers (sICAM, von Willebrand factor), and spirometric testing (FEV1, FVC, FEV1/FVC, VC). | — |
Countries
Netherlands
Outcome results
None listed