emotional blunting lack of initiative
Conditions
Interventions
All subjects receive a 10 mg methylphenidate challenge, a 500 µg pramipexole
challenge and a placebo condition.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Idopathic Parkinson's disease -Informed consent
Exclusion criteria
Exclusion criteria: -Other concurrent neurological diseases than PD -Concurrent psychiatric disease -Use of psychopharmacological medication -Abuse of alcohol and drugs -Cognitive deterioration as operationalized by a score of
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are the performance on neuropsychiatric and neuropsychological tests for both groups, including assessments of cognitive status, mood, apathy, and an observation of spontaneous self-reward behaviour. These outcome measures will be rated on three different testing days, before and after the administration of methylphenidate, pramipexole or placebo. | — |
Countries
Netherlands
Outcome results
None listed