Determinants of insulin-induced weight gain in patients with type 2 diabetes mellitus, a study on liver fat content, physical activity and metabolic markers comparing weight gainers vs. non-weight gainers

Determinants of insulin-induced weight gain in patients with type 2 diabetes mellitus, a study on liver fat content, physical activity and metabolic markers comparing weight gainers vs. non-weight gainers - Weight gain and insulin therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31007

Enrollment

Registered

2007-11-22

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: · Type 2 diabetes mellitus · Premixed insulin · Age 20-85 years · HbA1c 6 kg in any given period of 12 months (> 0.5 kg/months over 12 months) over a time period of 12-36 months after start of insulin therapy · Stable body weight · Current insulin dose >0.4 IU/kg -

Exclusion criteria

Exclusion criteria: · Clinical evidence of cardiovascular or liver or other disease · Treatment with drugs that may alter glucose tolerance, abnormal serum creatinine, macroalbuminuria, proliferative retinopathy, excessive alcohol consumption (>20 g/day), and drug abuse · Use of thiazolidinedione derivatives (TZDs) · Patients with pacemakers, ICD*s, implants of metal (prosthesis, (cochlear) ear implants) and patients who experience claustrophobia · Pregnancy or intention to become pregnant during the study

Design outcomes

Primary

Measure	Time frame
see objective of the study	—

Secondary

Measure	Time frame
see objective of the study	—

Countries

Netherlands

Outcome results