The role of adrenal stress hormones in emotional memory: formation, consolidation, and reconsolidation

The role of adrenal stress hormones in emotional memory: formation, consolidation, and reconsolidation - Stress and brain function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON30998

Enrollment

160

Registered

2007-07-17

Start date

2007-05-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stress related mental disorders

Interventions

Depending on the trial in which participants are classified, they will receive the following oral administrations: 40 mg propranolol and 2 * 750 mg metyrapone, or 2*750 mg metyrapone and 2 * 40 mg p

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Healthy male volunteers between 18 and 45 years of age. • Predominant right-handedness. • Body mass index between 18.5 and 30

Exclusion criteria

Exclusion criteria: • Metal objects in or around the body. • Claustrophobia. • History of psychiatric treatment or current psychiatric treatment. • History of neurological treatment or current neurological treatment. • History of endocrine treatment or current endocrine treatment. • History of heart related disease • Regular use of corticosteroids.

Design outcomes

Primary

Measure	Time frame
Functional MRI, memory performance, salivary levels of cortisol and alpha amylase, self-report questionnaires, and polysomnography (in one trial).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)