osteoarthritis
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Men or Women with hand osteoarthritis (according to ACR criteria) Older then 45 years Pain score 30 or more on VAS or visual analog function subscale of 225 or more of AUSCAN
Exclusion criteria
Exclusion criteria: Concomitant rheumatic disease Cutaneous psoriasis Underlying disease known to cause OA Rheumatoid factor or anti CCP antibody level above reference level Intra articular injection of one of the hand joints with corticosteroids or oral corticosteroid use less then 1 month prior to investigation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All hand joints will be studied on pain, swelling and loss of function. All joints will be scored using ultrasound on whether signs of inflammation are present or not. Analysis of the outcome measures of ultrasound findings of all painful hand joints will be compared to the outcome measures of non painful hand joints. Correction of patient characteristics will take place. A subanalysis will be performed within every patient. The outcome measures of the most painful joint (index joint) will be compared to a non painful osteoarthritic joint the contralateral hand preferably in the same joint or in the same row. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters will be a semi-quantative score on inflammation (0 to 3) using ultrasound of each hand joint. This might give relevant and more detailed information, but reliability of outcome measures might diminish. Also x-ray findings will be compared to clinical signs and ultrasound findings. | — |
Countries
Netherlands
Outcome results
None listed