The microcirculation in the pathogenesis of organ failure in patients with acute heart failure.

The microcirculation in the pathogenesis of organ failure in patients with acute heart failure. - CARMICI - protocol B

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30972

Enrollment

100

Registered

2007-11-12

Start date

2007-11-12

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiogenic shock severe heart failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Age of 18 years or older. 2. Admitted with the diagnosis acute heart failure (criteria: see protocol).

Exclusion criteria

Exclusion criteria: 1. Pregnancy (results in an altered hemodynamic state). 2. Oral bleeding.

Design outcomes

Primary

Measure	Time frame
1. Microvascular flow index, as obtained by SDF imaging. 2. Daily SOFA scores, as a measure for (multiple) organ failure. 3. Survival.	—

Secondary

Measure	Time frame
Data collection: 1. Clinical: Gender, age, length, weight, body temperature, Glascow Coma Scale, APACHE IV score, SAPS II score, diuresis. 2. (Macro)Hemodynamics: Heart rate, arterial blood pressure, central venous pressure, cardiac output, pulmonary artery pressure, pulmonary wedge pressure. 3. Respiratory: Positive end expiratory pressure (PEEP), respiratory rate. 4. Laboratory: Arterial blood gas analysis (pH, PaCO2, PaO2, SaO2), central venous blood gas analysis (ScvO2, PvCO2), lactate, glucose, hemoglobin (Hb), hematocrit (Ht), urea, creatinin, thrombocytes, leukocyrtes, PT/APTT/ACT. 5. Oxygen delivery: DO2=CO13.4[Hb]SaO2. 6. Oxygen uptake: VO2=CO13.4Hb(SaO2-SvO2).	—

Measure

Time frame

Data collection: 1. Clinical: Gender, age, length, weight, body temperature, Glascow Coma Scale, APACHE IV score, SAPS II score, diuresis. 2. (Macro)Hemodynamics: Heart rate, arterial blood pressure, central venous pressure, cardiac output, pulmonary artery pressure, pulmonary wedge pressure. 3. Respiratory: Positive end expiratory pressure (PEEP), respiratory rate. 4. Laboratory: Arterial blood gas analysis (pH, PaCO2, PaO2, SaO2), central venous blood gas analysis (ScvO2, PvCO2), lactate, glucose, hemoglobin (Hb), hematocrit (Ht), urea, creatinin, thrombocytes, leukocyrtes, PT/APTT/ACT. 5. Oxygen delivery: DO2=CO*13.4*[Hb]*SaO2. 6. Oxygen uptake: VO2=CO*13.4*Hb*(SaO2-SvO2).

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Countries

Netherlands

Outcome results