Colonoscopic surveillance using narrow-band imaging in patients with hyperplastic polyposis syndrome (HPS)

Colonoscopic surveillance using narrow-band imaging in patients with hyperplastic polyposis syndrome (HPS) - HYPON

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30966

Enrollment

Registered

2007-10-24

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polyps tumor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients presenting, or under surveillance at the Endoscopy Department of the AMC with: 1) *10 HPs found at colonoscopy, or 2) *5 HPs proximal to the sigmoid colon, or 3) Any number of HPs occurring proximal to sigmoid colon in an individual who has a first-degree relative with HPS

Exclusion criteria

Exclusion criteria: 1) history of inflammatory bowel disease, 2) severe coagulopathy, 3) age less than 18 years and 4) insufficient bowel preparation (

Design outcomes

Primary

Measure	Time frame
The sensitivity of WLE will be compared to that of NBI for the detection of polyps and cancer in the colon. The sensitivity of each technique will be calculated as the number of lesions detected during the first inspection, divided by the total number of lesions detected by both inspections. Furthermore, the surface pit pattern of the detected lesions on NBI will be used to obtain the overall accuracy (representing sensitivity and specificity) of this technique, by using the histological diagnosis as the gold standard diagnosis.	—

Measure

Time frame

The sensitivity of WLE will be compared to that of NBI for the detection of polyps and cancer in the colon. The sensitivity of each technique will be calculated as the number of lesions detected during the first inspection, divided by the total number of lesions detected by both inspections. Furthermore, the surface pit pattern of the detected lesions on NBI will be used to obtain the overall accuracy (representing sensitivity and specificity) of this technique, by using the histological diagnosis as the gold standard diagnosis.

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Secondary

Measure	Time frame
Moreover, the prevalence and distribution of HPs, SAs, MPs and adenomas in this patient population will be described.	—

Countries

Netherlands

Outcome results