rectal cancer
Conditions
Interventions
External beam raditoherapy
39 Gy will be given in 13 fractions of 3 Gy in 21 days
After 6 weeks a MRI will be performed and if the tumor thickness is:
* tumor 2 cm, patients will be treated with bra
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Histologically verified adenocarcinoma of the rectum within 15 cm of the anal verge, = 6 months -Patients who are unfit for surgical treatment, due to co-morbidity, or patients who refuse surgery -WHO
Exclusion criteria
Exclusion criteria: -Pregnant women -Patients with any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the feasibility and the maximum tolerated radiation dose in HDRBT of the rectum after EBRT in rectal cancer patients who are unfit for surgery or refuse surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| *To determine the incidence and severity of acute and late toxicity of EBRT followed by HDRBT *To determine the patient*s sphincter function *To determine the clinical tumor response of EBRT followed by HDRBT *To correlate the isodose lines of the irradiated tumor and normal tissue volumes with toxicity (HDRBT) | — |
Countries
Netherlands
Outcome results
None listed