Ankylosing Spondylitis
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients, between the age of 18 and 65, diagnosed with Ankylosing Spondylitis (AS) according to the New York Criteria for AS, with a BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) >4, eligible for anti-TNF therapy according to the national guidelines. Healthy controls: same gender, age within 5 years (and between 18 and 65) and family member of the respective patient.
Exclusion criteria
Exclusion criteria: Patients with other conditions known to affect energy metabolism (energy intake and/or expenditure) such as chronic inflammatory disorders (inflammatory bowel disease, COPD, rheumatoid arthritis,..), malignancies, AIDS, dieting will be excluded. Controls will be excluded when any disorder known to affect energy metabolism is present (Ankylosing Spondylitis or any disorder listed above). Subjects that meet any of the exclusion criteria for MRI (electronic implants, pacemakers, metal fragments in the eyes, skin or body) will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle mass (body compostition), physical activity, physical fitness, markers of inflammation and muscle metabolism | — |
Secondary
| Measure | Time frame |
|---|---|
| questionnaire assessed quality of life, disease activity, fatigue | — |
Countries
Netherlands
Outcome results
None listed