Pharmacokinetics of levetiracetam after rectal administration in healthy volunteers

Pharmacokinetics of levetiracetam after rectal administration in healthy volunteers - PK levetiracetam rectal

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30934

Enrollment

Registered

2007-12-17

Start date

2008-09-22

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy volunteers 18-55 years conformed consent

Exclusion criteria

Exclusion criteria: patients with epilepsia pregnant women breast feeding women bad renal function bad liver function

Design outcomes

Primary

Measure	Time frame
- Area-under- the-curve (AUC) - Relative bioavailability (Frel= AUCrectal/AUCoral)	—

Secondary

Measure	Time frame
- Maximum concentation (Cmax) - Time to maximum concentration (Tmax) - Clearance (Cl) - Volume of distribution (Vd) - Elimination constant (Kel) - Elimination half-life(T1/2)	—

Countries

Netherlands

Outcome results