Cerebral small vessel disease / Ischemic stroke
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria cerebral large vessel disease group TIA or stroke patients with one of the following: -clinically demonstrated loss of sensibility -clinically demonstrated loss of motor function;and including one or more of the following: -hemianopsia -aphasia -neglect;and a carotid stenosis of more than 70% at the ipsilateral side. Inclusion criteria cerebral small vessel disease group Patients with a clinically established lacunar syndrome (see appendix A) and lacunar infarcts and/or leukoaraiosis on CT.
Exclusion criteria
Exclusion criteria: Exclusion criteria for both groups are: -Age of less than 18 years -Incapacitated subjects -A Modified Rankin Scale (MRS) >3 -Diabetes Mellitus type I and II -Smoking -Iodine allergy -Hyperthyroidism Exclusion criteria cerebral large vessel disease group -Lacunar infarcts and/or leukoaraiosis on CT -Indication of a cardiac source of intracranial embolism;Exclusion criteria cerebral small vessel disease group -Carotid stenosis of more than 30% -Intermittent claudication -Angina pectoris -Myocardial infarction -Radiologically demonstrated cortical infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the difference in endothelial microvascular glycocalyx thickness between patients with cerebral small vessel disease and patients with large vessel atherosclerosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| The presence of blood parameters related to glycocalyx destruction in patients with cerebral small vessel disease. The presence of microalbuminuria in both research groups. The presence of pathological changes in microvessels found in skin biopsy. | — |
Countries
Netherlands
Outcome results
None listed