COLPOP '"Collagen metabolism in patients with and without Pelvic Organ Prolapse; a pilot study*

COLPOP '"Collagen metabolism in patients with and without Pelvic Organ Prolapse; a pilot study* - COLPOP Collagen metabolism and pelvic organ prolapse; a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30888

Enrollment

Registered

2007-11-13

Start date

2007-12-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cystocele pelvic organ prolaps rectocele

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Women with POP undergoing vaginal hysterectomy with anterior and/or posterior repair, 35-75 years of age - Women without POP undergoing abdominal or vaginal hysterectomy, 35-75 years of age

Exclusion criteria

Exclusion criteria: - No informed consent - Gynaecologic oncologic disease - Chronic inflammatory diseases (RA) of chronic infections (HIV, hepatitis) - Minors or incapacitated adults

Design outcomes

Primary

Measure	Time frame
Main study parameter/endpoint ·Determination of the production, crosslinking status and degradation profiles of the different collagen types in patients with and without POP in relation to age, parity, BMI, and POP status · Comparison of the collagen metabolism of differentiated stem cells and vaginal fibroblasts, of patients with and without POP.	—

Secondary

Measure	Time frame
Secundary study parameters Not applicable	—

Countries

Netherlands

Outcome results