induced anxiety in healthy volunteers
Conditions
Interventions
All subjects undergo a Fear-Potentiated Startle test in which anxiety is
induced by means of threat of electrical stimuli administered to the wrist, and
evoking startle reflexes as a read-out measur
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Subject is a legally competent adult, aged 18 to 40. - Subject is familiar with the procedures of the study, and agrees to participate in the study program by giving written informed consent.
Exclusion criteria
Exclusion criteria: - Subject is mentally or legally incapacitated, has significant emotional problems at the time of the study, or has a history of any significant psychiatric disorder(s). Subjects with extreme psychological responses in the personality questionnaires can be excluded. - Subject has a history of any cardiac disorder or neurological disease. - Subject has participated in another FPS trial prior to the start of the study. - Subject is currently a regular user (including *recreational uses*) of any illicit drugs, or has (a history of) drug or alcohol abuse. - Subject is unable to discern basic colours red, green and blue. - Reduced startle reactivity, defined as no discernable response in at least 3 out of the 12 startle stimuli.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is potentiation of the startle reflex during a condition in which electrical stimuli may be administered in comparison to startle during a safe condition in which electrical stimuli will never be presented (FPS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin conductance responses, subjective anxiety. | — |
Countries
Netherlands
Outcome results
None listed