"The role of the duodenum in symptom generation in GERD"

"The role of the duodenum in symptom generation in GERD" - "Duodenum and GERD symptoms"

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30855

Enrollment

Registered

2007-08-21

Start date

2007-11-29

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heartburn regurgitation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18-65 years old Recurrent heartburn, acid regurgitation and/or non cardiac chest pain At least 2 days per week for 3 months or more Diagnosis of GERD was established by 24-hour esophageal pH recording

Exclusion criteria

Exclusion criteria: Esophagitis C or D Barrett's esophagus Peptic ulcer disease Prior esophageal or gastrointestinal surgery Pregnancy Drug- or alcohol abuse

Design outcomes

Primary

Measure	Time frame
Differences in mRNA expression between GERD patients and healthy volunteers of at least a factor 1.5.	—

Secondary

Measure	Time frame
Significantly different apoA-IV concentrations in plasma and/or mucosal biopsies of GERD patients and healthy volunteers. Significantly different CCK concentrations in plasma and/or mucosal biopsies of GERD and healthy volunteers.	—

Countries

Netherlands

Outcome results