diabetes type 2 diabetes mellitus
Conditions
Interventions
During the 60-hour fast subjects are allowed to drink water and zero-calorie
drinks without caffeine ad libitum. In the control trial subjects will be fed
in energy balance and receive a diet which
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Male sex • Age 18-35 years • BMI
Exclusion criteria
Exclusion criteria: • Female sex • Unstable body weight (weight gain or loss > 3 kg in the past three months) • Participation in a regular exercise training program during the last year before the start of the study • Any medical condition requiring treatment and/or medication use • abuse of drugs and/or alcohol • participation in another biomedical study within 1 month before the first screening visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter is the difference in lipid accumulation and insulin sensitivity after prolonged fasting compared to the control trial. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary endpoints differences in lipid peroxidation, mitochondrial fatty acid export and mitochondrial damage between trials are considered. | — |
Countries
Netherlands
Outcome results
None listed