elevated blood pressure hypertension
Conditions
Interventions
Individuals are randomized to receive either lisinopril 10mg daily for three
weeks followed by lisinopril 20mg daily or matched placebo for a period of one
year. This is followed by two years of reg
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Included are persons aged 18-40 years with an average blood pressure of 130-139 systolic/below 90 mmHg diastolic and/or below 130 systolic/ 85-89 mmHg diastolic on 3 separate office visits with an interval of one week as measured by an automated blood pressure device (Omron M4).
Exclusion criteria
Exclusion criteria: Excluded are persons with any (chronic) disease requiring medication or specialist treatment, patients with 3 or more risk factors according to current ESH guidelines, an elevated baseline serum glucose or elevated serum creatinine and females with a wish to become pregnant in the treatment period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure 2 years after cessation of active treatment as evidenced by differences in 24 hour ambulatory blood pressure measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in left ventricular mass and microalbuminuria 2 years after active treatment. | — |
Countries
Netherlands
Outcome results
None listed