unexplained subfertility and mild male subfertility
Conditions
Interventions
INTERVENTIONS: Group A- 6 cycles intra-uterine insemination with controlled
ovarian hyperstimulation. Group B - 6 cycles MNC-IVF followed by IVF-eSET.
Group C - 3 cycles of IVF-eSET plus cryo-cycles
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Female age between 18 and 38 years. 2. Failure to conceive within at least 12 months of unprotected intercourse . 3. The couple has poor fertility prospects as calculated by the validated model of Hunault (Hunault et al., 2005, Van der Steeg et al., 2007). A poor fertility prospect is defined as a chance of spontaneous pregnancy below 30% within 12 months.
Exclusion criteria
Exclusion criteria: 1. Anovulation 2. Post-wash total motile sperm count below 3 million. 3. Double-sided tubal pathology 4. Endocrinopathological disease like: Cushing syndrome, adrenal hyperplasia, hyperprolactinemia, acromegaly, imminent ovarian failure, premature ovarian failure, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I. 5. Negative post-coitus test 6. If not willing or able to sign the consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is the birth of a healthy child. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are singleton and multiple ongoing pregnancy rates, clinical pregnancy rate, neonatal and maternal complications, patient preference and costs. | — |
Countries
Netherlands
Outcome results
None listed