parodontologische early wound healing healing parameters
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients maybe former smokers not consuming more than 5 cigarettes a day. Periodontitis patients, diagnosed with chronic periodontitis, not having experienced a subgingival cleaning/debridement at least one year before baseline of the study. Patients should have at least four maxillary teeth with probing pocket depth greater or equal 4mm. Also implants that are present are included. If affected teeth are endodontically treated clinical or radiographic analysis should resemble a successful endodontic treated tooth. Patients should be healthy except the diagnosis of chronic periodontitis. This excludes patients suffering from high blood pressure, other systemic diseases that might interfere with the distinction of blood, saliva or intrasulcular parameters. Patients forced to take prophylactic antibiotics before treatment are also excluded. Patients should not have any antiobiotic medication after six months before the start of the study.
Exclusion criteria
Exclusion criteria: Patients that are confirmed as heavy smokers are excluded. Therefore only former smokers (less or equal 5 cigarettes/day) are included in the study. Patients with systemic diseases, need for antiobiotic prophylaxis before treatment, patients with antibiotic treatment because of other reasons in the time interval of not more than 6 months before study start are also excluded. Further exclusion criteria is the receiving of a subgingival debridement shortly before baseline (less than one year).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cascade of certain wound healing parameters, biomarkers and cytokines will be described for the early wound healing by measuring levels and changes of IL-1beta, Interleukin-8, IL-1 alpha receptor antagonist, MMP8 and its tissue inhibitor TIMP-1 over a 3 months period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Probing pocket depth, gingival inflammation, plaque level | — |
Countries
Netherlands
Outcome results
None listed