Morbus Besnier Boeck Schaumann Sarcoidosis
Conditions
Interventions
None listed
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: · Evidence on the presence of active sarcoidosis is absent, over the last 6 months: - normal serum parameters (ACE, serum IL-2, calcium) - röntgenogram/CTscan: normal or >= 2 yr. stable - lungfuction: normal or >= 2 yr. stable (
Exclusion criteria
Exclusion criteria: · Sarcoidosis presented as Löfgren*s syndrome · Medication with corticosteroids or other immunosuppressive drugs over the last 6 months · Antidepressiva · Psychiatric diseases (major depression, schizophrenia, dementia, anorexia nervosa. bulimia nervosa) · Sleep apnoea or narcolepsy or restess legs syndrome · Any diagnosed disease or any significant abnormal and clinically relevant laboratory test that could possibly contribute to fatigue (Hb, BSE, leukocytes and differentiation, Na, K, Ca, creatine, bicarbonate, AF, ALAT, creatine phosphokinase (CPK), glucose, total protein, protein spectrum, thyroid stimulating hormone (TSH), ferritine en urine) · Body Mass Index (BMI): >= 45 or BMI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue: measured with the CIS20-questionnaire. The cut-off point for severe fatigue is set at a score of 40 or more on the subscale Severity of Fatigue (subscale scores ranges from 8 to 56). Measurements in serum: First Th1 / Th2 ratio will be determined. Secondly the ratio will be measured for the following cytokines: interferon (IFN)-g / IL-4. Lastly, IL-1 and IL6 will be analysed in the supernatants. Method to be used: LUMINEX. | — |
Secondary
| Measure | Time frame |
|---|---|
| HPA-axis (cortisol, ACTH), autonomous responses (catecholaminen, bloodpressure, heartfrequency), psychologic characteristics (cynical hostility), pain complaints, function of neuroanatomical pain pathways (LEP) and sensitisation (GRK). | — |
Countries
Netherlands
Outcome results
None listed