blood poisoning serious infection
Conditions
Interventions
Half of the included number of patients will receive a higher vancomycin dosage
at the start of therapy. However this dosage is within the limits of the normal
dosage range.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - children (age 0 to 18 yrs) - suspected or proven systemic infection with Gram-positive bacteria (incl. indwelling catheter infection) treated with intravenous vancomycin - written informed consent signed by both parents or the legal representative(s)
Exclusion criteria
Exclusion criteria: - renal failure (defined as a plasma creatinine concentration above the age corrected normal value) - renal replacement therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| During the study the following data will be collected centrally as part of the clinical research file: - length, body weight, age (for neonates also gestational age) - patient category (oncology, intensive car, neonate, other) - renal function (serum creatinine, blood urea nitrogen), fluid balance (if recorded as part of routine care) - reason for starting intravenous vancomycine therapy, dosage (dose en precise times of administration) - vancomycine serum concentrations, precise times of sampling, type of material - body temperature at the time of vancomycin administration - susceptibility and/or MIC of grown pathogens (bacteria) - registration of reported adverse effects | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed