insulin resistance resistance against the action of insulin
Conditions
Interventions
Disalcid is insoluble in acid gastric fluids but readily soluble in the small
intestine where it is partially hydrolyzed to two molecules of salicylic acid.
In contrast to acetylsalicylic acid (bett
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male sex - Age 18-30 years - BMI 20-25 kg/m2 - Stable dietary habits and physical activity levels
Exclusion criteria
Exclusion criteria: - Family history of diabetes - Medication use - Allergic to salsalate - Allergic to aspirin - Alcohol intake during 4 days prior to the clamp - Stomach ulcer - Impaired kidney function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As an outcome measurement, insulin sensitivity will be assessed by means of a hyperinsulinemic euglycemic clamp. | — |
Secondary
| Measure | Time frame |
|---|---|
| The following outcome parameters will be assessed: inflammatory markers, salsalate downstream genes, proteins involved in lipid handling (PKC), lipid metabolites in skeletal muscle; insulin sensitivity (hyperinsulinemic-euglycemic clamp); oxidative capacity (aerobic exercise test); body composition; mitochondrial markers and peripheral lipid accumulation in muscle (muscle biopsies); expression of proteins involved in fatty acid handling and insulin signalling in skeletal muscle (muscle biopsies). | — |
Countries
Netherlands
Outcome results
None listed