coagulation disorder Hypothyroidism: underactive thyroid gland low levels of thyroid hormone. Acquired von Willebrand syndrome: clotting protein deficiency
Conditions
Interventions
None listed
Sponsors
Slotervaartziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. 18 years or older, regardless of sex and race AND 2. Patients with a new diagnosis of primary overt hypothyroidism, before or within the first 48 hours of replacement therapy. Patients with autoimmune primary hypothyroidism will be enrolled in each hospital as the main population group. Also patients with temporary hypothyroidism will be enrolled as a subgroup population.
Exclusion criteria
Exclusion criteria: a. Secondary hypothyroidism b. Subclinical hypothryroidism c. Thyroid hormone replacement therapy > 48 hours at inclusion d. Known congenital or acquired von Willebrand syndrome e. Presence of a severe inflammatory disease (e.g. active inflammatory bowel disease, pneumonia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| von Willebrand factor antigen and activity (ristocetin cofactor), multimer pattern, factor VIII activity, and PFA-100, TSH, fT4, Hb, platelets, creatinin. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding history. | — |
Countries
Netherlands
Outcome results
None listed