Whole brain measurements of regional vasomotor reactivity in patients with carotid obstruction

Whole brain measurements of regional vasomotor reactivity in patients with carotid obstruction - CICERO study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON30734

Enrollment

120

Registered

2007-03-16

Start date

2008-01-23

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid occlusion and atherosclerosis

Interventions

All subjects will be administered a onetime dosis of 14 mg/kg acetazolamide.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - 18 years or older - Man or female - Patients with obstructive carotid artery disease or atherosclerosis

Exclusion criteria

Exclusion criteria: - Pregnancy or possible pregnancy - Severe liver or renal dysfunction - Diabetes Mellitus - Addison*s disease - Allergic reaction for sulfonamides - Cor pulmonale - Primary hyperaldosteronisme - Fenytoïne, primidon and/or fenobarbital use - Japanese and Indian subjects, or subjects of Japanese descent - Impossibility to undergo MRI (claustrophobia, metal objects in or around the body)

Design outcomes

Primary

Measure	Time frame
Regional changes in CBF (ml/min/100gr).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)