asthma
Conditions
Interventions
During the first phase none. When asthma is diagnosed, inhaled corticosteroids
will be prescribed.
Sponsors
Isala Klinieken
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - schoolchildren reffered to the pediatric out-patient clinic for diagnostics of exclusion of asthma - age 6-16 years - capable of performing reproducible lung function measurements at home - proper understanding of the dutch language - informed consent
Exclusion criteria
Exclusion criteria: - other chronic or acute disease capable of influencing the study results - refferal of children with an established diagnosis of asthma, who remain symptomatic despite treatement with inhaled corticosteroids. - respiratory tract infection or use of systemic corticosteroids 4 weeks prior to the start of the study - participation in another study - use of systemic corticosteroids or long-acting β2 sympathicomimetics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daily variation of PEF and FEV1 between the asthma and non asthma group and within the asthma group before and after the start of inhaled corticosteroids. | — |
Secondary
| Measure | Time frame |
|---|---|
| The cut-off point with the highest likelyhood ratio (sensitivity/1-specificity) for the golden standard of asthma diagnosis (pediatrician/pediatric-pulmonologist diagnosed asthma) wil be determined by performing receiver operating ratio (ROC)-analyses. This analysis is primarily 'pilot' based. The estimated power will be to low for definit conclusions. | — |
Countries
Netherlands
Outcome results
None listed