Kidney transplantation
Conditions
Interventions
Mainly the selection of suitable donors will change for a certain patient. The
medical procedure of the transplantation will not differ from that of other
renal transplant recipients besides the fac
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Older than 18 years. Patients with renal failure on the Eurotransplant kidney waiting list. PRA in historical sera higher than 85%. More than 1 year on the AM list. A signed "informed consent" form.
Exclusion criteria
Exclusion criteria: 1) Patients with severe gastrointestinal disorders, that interfere with their ability to receive or absorb oral medication and patients with severe diarrhea. 2) Patients with active peptic ulcer disease. 3) Patients or their donors with serologic evidence of HIV, HCV or HBsAg in the past. 4) Patients with malignancies (current or history within last 5 years) except non metastatic basal or squamous cell carcinoma of the skin that has been treated successfully. 5) Patients with systemic infection requiring therapy at the time of entry in the study. 6) Patients with any form of substance abuse or psychiatric disorder which in the opinion of the investigator might invalidate patients communication with the clinician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Finding new Acceptable HLA mismatches and leading to an increased chance to get an organ offer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are patient and graft survival, graft function as assessed by calculated creatinine clearance, proteinuria, the number and severity of acute (antibody mediated) rejections, blood pressure (antihypertensive treatment), monitoring of infections and the occurrence of malignancies. | — |
Countries
Netherlands
Outcome results
None listed