inflammatory neuropathies nerve diseases
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with MMN: 1) weakness and atrophy of the limbs on neurological examination, 2) motor conduction block (CB) on extensive standardized nerve conduction studies according to criteria previously defined by our group. Inclusion criteria for patients with CIDP: 1) presence of progressive or relapsing motor (muscle weakness) or sensory (numbness, tingling) dysfunction of more than one limb (both proximally and distally), 2) hyporeflexia or areflexia of the limbs, 3) abnormalities on nerve conduction studies indicative of demyelination (conduction block, increased temporal dispersion, absent F-waves or increased F- M latency, or reduction of conduction velocity). Inclusion criteria for patients with LMND: 1) weakness, atrophy, and fasciculations in the limbs, 2) electrophysiological evidence of lower motor neuron involvement (denervation and/ or reinnervation) on needle EMG examination in clinically affected and nonaffected muscles without evidence of conduction block.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with MMN: 1) objective sensory signs on neurological examination, 2) clinical signs of upper motor neuron involvement (pseudobulbar symptoms, clonus of masseter reflex, hyperreflexia hypertonia or extensor plantar responses of the limbs). Exclusion criteria for patients with CIDP: 1) duration of signs and symptoms shorter than 2 months, 2) elevated (>10/mm3) white cell count of cerebrospinal fluid with elevated protein levels. Exclusion criteria for patients with LMND: 1) history of diseases that may mimic LMND (acute poliomyelitis, spinal radiculopathy, diabetic amyotrophy, thyrotoxicosis or hyperparathyroidism), 2) clinical signs of upper motor neuron involvement (see above), 3) objective sensory signs on neurological examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -indications of or evidence for activity-dependent conduction block -indications of or evidence for depolarizing conduction block | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed