addiction schizophrenia substance abuse
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * History of mild cannabis use for at least one year (4/year) * History without psychotic experiences after cannabis use * Age between 18 and 45 years * Right-handedness, assessed with the Edinburgh Handedness Inventory * Written informed consent of the subject
Exclusion criteria
Exclusion criteria: * Any clinical significant abnormality of any clinical laboratory test, including drug screening * Impaired physical health evaluated by medical history, physical (including neurological) examination and screening laboratory tests * History of clinically significant psychiatric or neurological illness * History of clinically significant psychiatric or neurological illness in first- or second-degree relatives * History of alcohol and/or drug abuse (DSM-IV criteria) * Body Mass Index (B.M.I.) 28 kg/m2 * Paranoid ideation or psychoticism on SCL-90 * Any subject who received any investigational medication within 90 days prior to the start of the study or who is scheduled to receive an investigational drug * The use of any medication within three weeks prior to the start of the study, except for paracetamol * Positive HIV or Hepatitis B/C test * Blood donation within 3 months before the start of the study * Claustrophobia * Metal objects in or around the body (braces, pacemaker, metal fragments)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the blood-oxygen-level dependent (BOLD) signal. | — |
Secondary
| Measure | Time frame |
|---|---|
| Further, behavioral parameters and the concentration of plasma THC and its main metabolites will be obtained. | — |
Countries
Netherlands
Outcome results
None listed