Hypothyroidism slow thyroid
Conditions
Interventions
During the study, patients will have to take 2 tablets a day (one in the
morning and one at bedtime), instead of 1 tablet. During these 16 weeks they
will return to the outpatient department five ti
Sponsors
Medisch Centrum Rijnmond-Zuid
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age > 18 years At least 6 months on a stable regimen of levothyroxine, with TSH 0.4-4.0 mU/l
Exclusion criteria
Exclusion criteria: Pregnancy Disease of the stomach, jejunum or ileum Use of medication known to interfer with the uptake of levothyroxine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint will be a significant change in TSH and thyroid hormones FT4/T3 with a switch to the bedtime administration of levothyroxine compared to the morning administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary endpoints will be a change in blood pressure, pulse, weight, other lab results (ferritin, albumin, lipids etc.), a change in quality of life and symptoms of hypo-or hyperthyroidism. Furthermore we will study if patients that were subclinically hypothyroid, and become euthyroid or (subclinically) hyperthyroid because of the different administration time of levothyroxine, have a change in quality of life. | — |
Countries
Netherlands
Outcome results
None listed