Effects of caloric restriction and weight loss on hypothalamic function in response to glucose ingestion in patients with type 2 diabetes mellitus.

Effects of caloric restriction and weight loss on hypothalamic function in response to glucose ingestion in patients with type 2 diabetes mellitus. - Effects of caloric restriction on hypothalamic function in DM2

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON30633

Enrollment

Registered

2007-07-16

Start date

2007-03-17

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes diabetes mellitus type 2

Interventions

Participants are on a low calorie diet for 6 weeks. During this period they will undergo a fMRI examination that also comprises drinking of 300 ml glucose solution.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male, Body Mass Index (BMI) higher than 25 kg/m2 with a maximum of 30 kg/m2, age 40-60 years, Diabetes type 2

Exclusion criteria

Exclusion criteria: Impaired renal function (serum creatinine > 176 µmol/L). Use of SU derivatives or insuline Leg ulcers, gangrene. Blood pressure > 160/100 mmHg with or without antihypertensive drugs. Contra indications MRI: p.e. pacemaker, aneurism clips, metallic implants, neurostimulator, metal foreign bodies, hydrocephalus pump, claustrophobia

Design outcomes

Primary

Measure	Time frame
Changes in reaction pattern of neuronal activity (as measured with fMRI) in the hypothalamus in respons to intake of glucose in patients with diabetes type 2, before caloric restriction and after 3 days and 6 weeks low calorie diet (i.e. before and after weight loss).	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)