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Correlation between oxidative stress and microvascular perfusion defects in renal ischemia/reperfusion injury during kidney transplantation: an observational study.

Correlation between oxidative stress and microvascular perfusion defects in renal ischemia/reperfusion injury during kidney transplantation: an observational study. - Oxidative stress and microvascular perfusion during kidney transplantation.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON30630
Enrollment
40
Registered
2007-06-13
Start date
2007-12-10
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemia/reperfusion injury Kidney transplantation

Interventions

None listed

Sponsors

Academisch Ziekenhuis Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Kidney transplant recipient (living donor [and their donors] / deceased heart-beating donor / deceased non-heart-beating donor). Partial nephrectomy with clamping of the renal vascular pedicle.

Exclusion criteria

Exclusion criteria: Age 60 years

Design outcomes

Primary

MeasureTime frame
Oxidative stress: 1. Renal arterio-venous difference in plasma F2-isoprostanes concentration. 2. Tissue F2-isoprostanes concentration. 3. Urine F2-isoprostanes concentration. 4. Advanced glycation end products (AGE*s) measured by skin autofluorescence. Renal perfusion: 1. Renal artery flow measured by Laser-Doppler flow probe. 2. Microcirculatory perfusion measured by OPS imaging (parameters: volumetric blood flow, functional capillary density).—

Secondary

MeasureTime frame
Kidney function: 1. Dialysis dependency after transplantation. 2. Area under the curve for serum creatinine concentration over time (14 days). 3. Fractional excretion of sodium (14 days). Inflammation: Serum cytokine concentrations (IFN-γ, TNF-a, IL-6, IL-10, IL-17, IL-23). Renal cellular injury: Urine NGAL and NAG concentrations. Anti-oxidants: vitamin C, vitamin E, GSH/GSSG ratio, total anti-oxidant capacity. Endothelial glycocalyx: 1. Thickness measured by OPS imaging 2. Renal arterio-venous differences in syndecan-1, heparin sulphate and hyaluronan concentrations.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)