tetralogy of Fallot
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: Diagnosis: Tetralogy of Fallot. Only patients that previously had systematic evaluation of medical history, clinical status, MRI, ECG, excercise performance and biomarkers of ventricular remodeling.
Exclusion criteria
Exclusion criteria: Diagnosis of major systemic-pulmonary collateral arteries Residual pulmonary stenosis with a gradient of > 40 mm Hg (Doppler) Residual VSD, aortic stenosis and/or regurgitation Residual arterial desaturation Complete repair with homograft Absent pulmonary valve Syndrome Mental retardation Pulmonary valve replacement secondary to tetralogy correction Contra-indications to MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures are differences between baseline (already available) and current (to be obtained in this project): 1) RV end-systolic volume 2) RV ejection fraction 3) NYHA functional class 4) maximal oxygen uptake 5) maximal workload 6) biomarkers | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify, chracterize and quantify markers in blood samples, using high density antibody arrays and ELISAs, obtained from Fallot patients at different stages of development of RV overload and hypertrophy, Correlate circulating levels of identified markers with cardiac an systemic parameters, and to identify (a) potential biomarker(s) as a diagnostic and prognostic tool(s) | — |
Countries
Netherlands
Outcome results
None listed