The reservecapacity of the peritoneum with the NO donor sodium nitroprusside during peritoneal dialysis

The reservecapacity of the peritoneum with the NO donor sodium nitroprusside during peritoneal dialysis - Peritoneal reservecapacity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30602

Enrollment

Registered

2007-07-31

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aandoeningen ten gevolge van behandeling met peritoneale dialyse als nierfunctie vervangende therapie peritoneal membrane failure = impairment to remain on a certain dry weight with peritoneal dialysis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients > 18 years of age treated with peritoneal dialysis > 1 month and 18 years of age treated with peritoneal dialysis > 3 years

Exclusion criteria

Exclusion criteria: Patients with peritonitis less than 4 weeks prior the investigation Severe overhydration Signs of hypersensitivity for dextrans Systolic bloodpressure

Design outcomes

Primary

Measure	Time frame
The main study parameter is the difference in transport of small solutes by means of the mass transfer area coefficient (MTAC) of creatinine between the SPA with and without the addition of the vasodilator sodium nitroprusside. The difference in MTAC-creatinine between these SPAs will be compared between the short-term and the long-term PD group.	—

Secondary

Measure	Time frame
Secondary study parameters will be differences between the SPA with and without sodium nitroprusside in: - Peritoneal solute transport of other small solutes: MTACs of the small solutes urea, urate and dialysate over plasma ratios (D/P) of creatinine, urea, urate, peritoneal glucose absorption - Intrinsic permeability for macromolecules: clearances of 2-Microglobulin, albumin, immunoglobulin-G, 2-macroglobulin - Peritoneal fluid kinetics - Pore sizes of the peritoneal membrane The baseline characteristics (age, gender, PD duration, end stage renal disease), markers for the peritoneal membrane, peritoneal membrane thickness of the patients will be described and analyzed for differences between the 2 groups.	—

Measure

Time frame

Secondary study parameters will be differences between the SPA with and without sodium nitroprusside in: - Peritoneal solute transport of other small solutes: MTACs of the small solutes urea, urate and dialysate over plasma ratios (D/P) of creatinine, urea, urate, peritoneal glucose absorption - Intrinsic permeability for macromolecules: clearances of *2-Microglobulin, albumin, immunoglobulin-G, *2-macroglobulin - Peritoneal fluid kinetics - Pore sizes of the peritoneal membrane The baseline characteristics (age, gender, PD duration, end stage renal disease), markers for the peritoneal membrane, peritoneal membrane thickness of the patients will be described and analyzed for differences between the 2 groups.

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Countries

Netherlands

Outcome results