Pedigree research in families with Common Variable Immunodeficiency Disease.

Pedigree research in families with Common Variable Immunodeficiency Disease. - CVID families

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30598

Enrollment

Registered

2007-11-06

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

common variable immunodeficiency disease late onset hypogammaglobulinemia

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: *patients with CVID treated at the department of pediatrics of the Jeroen Bosch Hospital. *genetic interesting relatives of the CVID patients, based on the family history and pedigree. *relatives with suspicion of immunodeficiency based on clinical records.

Exclusion criteria

Exclusion criteria: Illness or recent infection (

Design outcomes

Primary

Measure	Time frame
1. With the help of department of clinical genetics: to make a pedigree of the two families with CVID to see if they are related to each other. Are there enough clues for genetic testing? 2. To determine immunologic parameters in CVID-patients and family members with recurrent infections or other symptoms of CVID.	—

Secondary

Measure	Time frame
1. If there are enough clues for a genetic background of CVID in a family: genetic testing of known CVID-genes. 2. If a genetic mutation is found: is there a correlation between immunologic parameters and the found mutation?	—

Countries

Netherlands

Outcome results