Differences in inflammatory and hemostatic response in cardiac surgery patients operated with conventional Cardiopulmonary Bypass (CPB) versus Minimized Extracorporeal Circulation (MECC).

Differences in inflammatory and hemostatic response in cardiac surgery patients operated with conventional Cardiopulmonary Bypass (CPB) versus Minimized Extracorporeal Circulation (MECC). - MECCSI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30590

Enrollment

Registered

2007-08-02

Start date

2008-07-14

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inflammation and hemostase and extracorporal circulation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients> 18 years undergoing elective CABG with Cardiopulmonary bypass (CPB) in the Antonius hospital in Nieuwegein

Exclusion criteria

Exclusion criteria: Emergency patients, patients with inborn coagulation disorders and patients on immunosuppressive therapy.

Design outcomes

Primary

Measure	Time frame
The primary objective of this study is to define differences in the inflammatory response, coagulation, and fibrinolysis in CABG patients with MECC or conventional CPB. To compare inflammation and coagulation activation between MECC and conventional CPB patients several inflammatory and coagulation parameters in the blood are measured. Thromboelastography (TEG) is used to compare the hemostatic process between the groups.	—

Measure

Time frame

The primary objective of this study is to define differences in the inflammatory response, coagulation, and fibrinolysis in CABG patients with MECC or conventional CPB. To compare inflammation and coagulation activation between MECC and conventional CPB patients several inflammatory and coagulation parameters in the blood are measured. Thromboelastography (TEG) is used to compare the hemostatic process between the groups.

—

Secondary

Measure	Time frame
Differences in blood product transfusion numbers, hospital and ICU length of stay, bloodloss and mechanical ventilation duration, and myocardial damage (CK> 180 U/l with CK-MB > 10% of total and troponine-T> 0,1).	—

Countries

Netherlands

Outcome results